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About Safeheart® Soft

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Safeheart® Soft is manufactured by SavaVet. It comes in a form of chewable tablets that are easy to take for dogs. The active ingredient of these tablets is Pimobendan, a positive inotrope, calcium sensitizer, and selective inhibitor of phosphodiesterase 3 (PDE3).


- as an add-on therapy in management of mild to severe congestive heart failure associated with AVVI or DCM in dogs.

Safeheart® Soft strengthens heart muscles, reduces cardiac fatigue, and dilates arteries and veins increasing tissue perfusion and minimizing tissue congestion. Be aware that the sole consumption of Safeheart® Soft does not cure heart diseases or stop heart attacks.

MOA (mechanism of action):

Pimobendan increases myocardial contractility (an ability of heart muscles to contract), so that the heart can undergo the stress loads more easily. Pimobendan also causes peripheral vasodilation and stimulates the ability to produce force during contraction. Namely, it inhibits the function of phosphodiesterase III and increases the binding of cardiac troponin to the calcium ions, thereby promoting the concentration of calcium in the cells – factor directly responsible for the aforementioned binding and contraction force as well. By these actions, Pimobendan decreases blood flow resistance through capillaries and relieves afterload.


Safeheart® Soft should be taken by mouth and chewed thoroughly.

The total daily dose is 0,5 mg/kg bodyweight divided in two intakes approximately 12 hours apart (e. g., in the morning and at bedtime).

The tablets can be cut if needed to provide the exact dose calculated for your dog depending on its bodyweight.

The exact course duration must be determined by your veterinarian.

If you are struggling with giving tablets to your dog, Safeheart® Soft tablet may be disguised in a small bite of moist food, so that your dog would like to eat it.

Missing a dose

If you miss a dose you should give it as soon as you remember about your missing. If it is the time for the next dose you should continue the regular dosing schedule. Do not exceed the recommended dosage. Do not administer a double dose to compensate the missed one.


If an overdose occurs and your pet is feeling unwell, stop giving the medication immediately and seek medical advice.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with the use of Safeheart® Soft are:

  • loss of appetite
  • lack of energy
  • diarrhea
  • shortness of breath
  • azotemia
  • ataxia

Do not give Safeheart® Soft to your dog if it is allergic to Pimobendan.

Do not use Safeheart® Soft in case of hypertrophic cardiomyopathy, aortic stenosis, or any other clinical condition where an augmentation of cardiac output is inappropriate for functional or anatomical reasons.

Do not give Safeheart® Soft to dogs with asymptomatic heart disease or in heart failure caused by etiologies other than AVVI or DCM without your veterinarian’s approval.

Do not give Safeheart® Soft to the puppies under 6 months of age.

Do not give Safeheart® Soft to dogs with congenital heart defects, diabetes mellitus, and other serious metabolic diseases.

Dogs which are used for breeding, pregnant or lactating should consume Safeheart® Soft under veterinarian supervision.

Always give your veterinarian the list of all medications (prescription or non-prescription) and herbal supplements you are giving to your pet.

Do not use Safeheart® Soft in people.

Q: What is Safeheart® Soft used for?

A: Safeheart® Soft is an oral drug used to support cardiac health in dogs suffering from congestive heart failure in dogs due to atrioventricular valvular insufficiency (AVVI) or dilated cardiomyopathy (DCM). The regular use of Safeheart® Soft normalizes heart rate, improves exercise tolerance, and prolongs lifetime. Formulated for veterinary use in dogs only. Suitable for adult dogs and puppies over 6 months of age.

Q: Is Safeheart® Soft safe?

A: Yes, Safeheart® Soft is safe as long as used for prescribed conditions and at prescribed doses.

Q: Can I give Safeheart® Soft to my pregnant dog?

A: Dogs which are used for breeding, pregnant or lactating should consume Safeheart® Soft under veterinarian supervision.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide Shipping

Worldwide Shipping

Registered Mail  Not trackable 14-21 business days USD 20.00 per order
EMS  Trackable, where available 5-9 business days USD 30.00 per order

Delivery time is:

Registered Mail - 14-21 business days, price - USD 20.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 30.00, signature is required on delivery.
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